MOTS-C 5MG

The Mitochondrial-Derived Peptide for Metabolic Health, Exercise Performance & Longevity

MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded in mitochondrial DNA that regulates metabolic homeostasis, insulin sensitivity, and cellular energy production. Discovered in 2015, MOTS-c represents a new class of signaling molecules - mitochondrial-derived peptides (MDPs) - that communicate between mitochondria and the nucleus to optimize metabolism. The peptide mimics the beneficial metabolic effects of exercise, enhances glucose and fat metabolism, improves insulin sensitivity, and may contribute to healthy aging by supporting mitochondrial function.

What makes it unique: MOTS-c is encoded by mitochondrial DNA (not nuclear DNA like most proteins), making it part of an emerging class of mitochondrial-derived regulatory peptides. It acts as a "metabolic regulator" - improving how cells produce and use energy, enhancing insulin sensitivity without lowering blood sugar in healthy individuals, and mimicking exercise's metabolic benefits. MOTS-c essentially helps cells become more metabolically efficient, burning fuel better and responding more appropriately to metabolic signals.

Clinical significance: Research demonstrates MOTS-c declines with age and metabolic dysfunction, potentially contributing to age-related metabolic decline. Supplementation improves glucose metabolism, enhances insulin sensitivity, increases exercise capacity, promotes fat oxidation, and shows promise for metabolic syndrome, type 2 diabetes risk reduction, and healthy aging. MOTS-c activates AMPK (master metabolic regulator) and improves mitochondrial function - addressing metabolism at the most fundamental cellular level.

Primary effects: Improved insulin sensitivity and glucose metabolism, enhanced fat oxidation and metabolic flexibility, increased exercise endurance and performance, better cellular energy production (ATP), reduced metabolic inflammation, improved muscle function and recovery, potential longevity benefits through metabolic optimization, and overall metabolic health support - particularly valuable for those with insulin resistance, metabolic syndrome, or age-related metabolic decline.

Who this is for: Women with insulin resistance or prediabetes seeking metabolic improvement, those with metabolic syndrome wanting comprehensive metabolic support, athletes seeking enhanced endurance and recovery, anyone 40+ experiencing age-related metabolic decline, women interested in longevity and healthspan optimization, those wanting exercise-mimetic benefits, or anyone focused on metabolic health and efficiency - with understanding MOTS-c works best combined with proper diet, exercise, and lifestyle rather than replacing them.

Product Specifications:

• Purity: ≥98% (HPLC tested)
• Form: Sterile lyophilized powder
• Quantity: 5mg per vial
• Sequence: 16 amino acids (MRWQEMGYIFYPRKLR)
• Storage: Refrigerate 2-8°C, protect from light (freezer for long-term)
• Dosing: 2-3x weekly or daily, flexible timing
• Includes: Vial