DETAILS
A COMPLETE GUIDE TO CJC-1295 NO DAC
How CJC-1295 No DAC Works
Modified GRF 1-29 operates by amplifying natural GH pulses, particularly when combined with GHRPs for maximum synergy.
What is Modified GRF 1-29:
The original peptide:
- Based on Growth Hormone Releasing Hormone (GHRH)
- GHRH fragment (amino acids 1-29)
- Four amino acid substitutions for stability
- Also called "Tetrasubstituted GRF(1-29)"
- This is what "CJC-1295 No DAC" refers to
Key modifications:
- Ala² → D-Ala² (position 2)
- Gln⁸ → Gln⁸ (position 8, enhanced stability)
- Ala¹⁵ → Leu¹⁵ (position 15)
- Gln²⁰ → unmodified (position 20)
- These changes increase half-life from ~7 minutes (natural GHRH) to ~30 minutes
Still short half-life compared to WITH DAC:
- Modified GRF: ~30 minutes
- CJC with DAC: 6-8 days
- This short duration is actually an advantage for pulsatile approach
Why "No DAC" Matters:
What DAC is:
- Drug Affinity Complex
- Chemical modification that binds albumin
- Extends half-life to days
- Creates sustained GH elevation
Why NOT having DAC is beneficial:
- Allows natural pulsatile GH pattern
- Creates short, powerful GH spikes
- Returns to baseline between doses
- Enables GHRP synergy (both pulsed together)
- More "physiological" approach
- Better for multiple daily pulses
The Pulsatile GH Pattern:
Natural GH secretion:
- Episodic pulses throughout day
- Largest pulse during deep sleep
- 6-10 pulses per 24 hours in youth
- Sharp spikes then return to baseline
- This pattern is important for optimal effects
Modified GRF mimics this:
- Injection → GH spike within 30-60 minutes
- Peak GH levels
- Return to baseline by 2-4 hours
- Ready for next pulse
- Can dose 1-3x daily creating multiple pulses
Why pulsatile may be superior:
- Mimics youthful secretion pattern
- Prevents receptor desensitization (theoretical)
- Allows for GHRP synergy
- More natural metabolic effects
- Better insulin sensitivity long-term (theoretical)
The GHRH + GHRP Synergy - The Key Mechanism:
Why this combination is revolutionary:
GHRH (Modified GRF) pathway:
- Binds GHRH receptors on pituitary
- Stimulates GH release
- Moderate GH elevation alone (2-3x baseline)
GHRP (Ipamorelin, GHRP-2/6) pathway:
- Binds ghrelin receptors (GHS-R)
- Different pituitary pathway
- Moderate GH elevation alone (3-5x baseline)
When combined together:
- BOTH pathways activated simultaneously
- Synergistic amplification (not just additive)
- GH elevation: 8-15x baseline or more
- This is the magic of peptide protocols
- Approaches pharmaceutical GH levels naturally
The science:
- GHRH tells pituitary "release GH"
- GHRP tells pituitary "release GH NOW and AMPLIFY"
- Together: massive coordinated pulse
- This is why Modified GRF + GHRP is gold standard
Important: Modified GRF alone = modest effects. Modified GRF + GHRP = powerful effects. ALWAYS stack together.
Timing for Synergy:
Critical for maximum effect:
- Dose Modified GRF and GHRP at SAME TIME
- Both must hit bloodstream together
- Can mix in same syringe (common)
- Synergy requires simultaneous action
- Timing mismatch = lost synergy
This is why short half-life is advantage - allows precise timed pulses.
GH and IGF-1 Effects:
Acute (per pulse):
- GH spike 30-60 min post-injection
- Peak levels 1-2 hours
- Return toward baseline 2-4 hours
- IGF-1 rises gradually (liver produces from GH)
Cumulative (daily/weekly):
- Multiple pulses throughout day
- IGF-1 remains elevated (longer half-life than GH)
- Sustained anabolic environment from IGF-1
- Pulsatile GH with sustained IGF-1 = optimal
Benefits of GH/IGF-1 Elevation:
Anabolic (muscle building):
- Enhanced protein synthesis
- Increased nitrogen retention
- Muscle cell proliferation
- Satellite cell activation
- Gradual lean mass gains
Lipolytic (fat burning):
- Stimulates fat breakdown
- Inhibits fat storage
- Preferential visceral fat mobilization
- Improved body composition
Recovery & repair:
- Enhanced tissue repair
- Improved sleep quality
- Faster recovery from training
- Better connective tissue health
Anti-aging:
- Skin quality improvement
- Bone density support
- Immune function
- Overall vitality
Primary Uses & Applications
1. GHRH + GHRP Stack for Maximum GH Optimization (PRIMARY USE)
The gold standard protocol:
Modified GRF + Ipamorelin (Most Popular):
- Clean, side-effect-free combination
- 8-15x GH elevation when dosed together
- Optimal for body composition
- Excellent for women (minimal side effects)
Modified GRF + GHRP-2:
- More powerful GH release than Ipamorelin
- Moderate appetite increase (can help or hinder)
- Slightly more side effects (hunger, possible nausea)
- Good for those wanting maximum GH
Modified GRF + GHRP-6:
- Strongest GH release of all GHRPs
- Significant appetite increase (excellent for bulking)
- More side effects
- For serious muscle building goals
Effects of proper stacking:
- Muscle growth (3-8 lbs over 3-6 months)
- Enhanced fat loss
- Superior recovery
- Improved sleep
- Anti-aging benefits
- Comprehensive physique transformation
This is what Modified GRF was designed for - synergistic GHRP stacking.
2. Multiple Daily Pulses for Youthful GH Pattern
Mimicking youth:
Young people: 6-10 GH pulses daily
Aging adults: 2-4 pulses, smaller amplitude
Modified GRF + GHRP protocol recreates youthful pattern:
- 1-3 doses daily = 1-3 powerful pulses
- Restores more youthful secretion
- Better overall GH exposure
- Optimal for anti-aging
3. Flexible Timing Around Training
Performance optimization:
Pre-workout pulse:
- 30 min before training
- GH elevation during workout
- Enhanced performance potential
- Better nutrient partitioning
Post-workout pulse:
- Immediately after training
- Optimal recovery window
- Enhanced muscle protein synthesis
- Improved adaptation
Most effective: Post-workout + before bed (2x daily minimum)
4. Sleep Quality Enhancement
GH and deep sleep:
Before bed dosing:
- 30 min before sleep
- GH pulse during sleep onset
- Enhanced deep (slow-wave) sleep
- Better sleep architecture
- More restorative rest
- This is one dose everyone should include
5. Anti-Aging Without Sustained Elevation
For those concerned about chronic GH:
Pulsatile advantages:
- Mimics natural pattern
- Returns to baseline between doses
- May be safer long-term
- Avoids constant GH exposure
- Better insulin sensitivity (theoretical)
- Still provides anti-aging benefits
Research Dosing Protocols
Standard GHRH + GHRP Dosing:
Modified GRF 1-29 (GHRH):
- 100-200mcg per injection
- Most common: 100mcg
- Dosed with GHRP simultaneously
GHRP (Ipamorelin, GHRP-2/6):
- 100-300mcg per injection
- Most common: 100-200mcg
- Dosed with Modified GRF simultaneously
Standard Protocol Examples:
Beginner (Conservative):
- Modified GRF: 100mcg + Ipamorelin: 100mcg
- Before bed only (1x daily)
- Simplest effective protocol
- Good starting point
Intermediate (Common):
- Modified GRF: 100mcg + Ipamorelin: 200mcg
- Post-workout + before bed (2x daily)
- Excellent results
- Most popular protocol
Advanced (Maximum Natural):
- Modified GRF: 100-200mcg + GHRP-2: 200-300mcg
- Morning + post-workout + before bed (3x daily)
- Maximum GH optimization
- Demanding schedule
- Strongest results
Frequency Guidelines:
Once Daily (Minimum):
- Before bed
- Timing: 30 min before sleep
- Simplest protocol
- Still very effective
- Good for sleep and recovery
Twice Daily (Optimal for Most):
- Post-workout + before bed
- OR morning fasted + before bed
- Excellent balance of results and convenience
- Most common approach
- Great body composition changes
Three Times Daily (Maximum):
- Morning fasted + post-workout + before bed
- Spacing: Minimum 3-4 hours between doses
- Maximum GH exposure
- Best results but demanding
- For serious goals
Timing Specifics:
Morning Fasted (Optional 1st dose):
- Upon waking, 3+ hours fasted
- Amplifies fasted GH levels
- Enhanced fat oxidation
- Wait 20-30 min before eating
Post-Workout (Highly Recommended):
- Immediately after training
- Or within 30 minutes
- Optimal recovery window
- Enhanced nutrient partitioning
- Many consider this essential
Before Bed (ESSENTIAL - Never Skip):
- 30 minutes before sleep
- Aligns with natural nocturnal GH pulse
- Enhances deep sleep
- Most important single dose
- Universal recommendation
Critical Timing Rules:
Always fasted:
- 3+ hours after last meal
- Food (especially carbs) blunts GH response
- Glucose and insulin inhibit GH secretion
- Wait 20-30 min post-injection before eating
Dose GHRH + GHRP together:
- Inject within minutes of each other
- Can mix in same syringe
- Synergy requires simultaneous action
- Don't separate timing
Spacing between doses:
- Minimum 3-4 hours apart
- Allows GH to return to baseline
- Prevents receptor desensitization
- Maintains pulse effectiveness
Cycle Duration:
Typical cycles:
- 8-16 weeks continuous use
- Followed by 4-8 week break
- Or continuous use indefinitely
Some approaches:
- 5 days on, 2 days off (weekday only)
- 8 weeks on, 4 weeks off
- Continuous year-round
- All approaches used successfully
No strict cycling requirement - effects sustained with long-term use.
Reconstitution:
For 5mg vial Modified GRF:
Mix with 2.5ml bacteriostatic water = 2mg/ml (2000mcg/ml)
- For 100mcg dose: 0.05ml (5 units)
- For 200mcg dose: 0.1ml (10 units)
Can also mix in same syringe as GHRP (common practice):
- Draw Modified GRF first
- Then draw GHRP
- Both in same syringe
- Single injection
Vials Needed (Modified GRF + Ipamorelin Example):
At 100mcg each, 2x daily:
- Modified GRF: 200mcg daily = 25 days per 5mg vial
- Ipamorelin: 200mcg daily = 25 days per 5mg vial
- Monthly: ~1-2 vials each peptide
At 100mcg each, 3x daily:
- 300mcg daily each peptide
- ~16 days per 5mg vial
- Monthly: ~2 vials each
Modified GRF + GHRP stack moderately priced for powerful effects.
Stacking & Combinations
Modified GRF + Ipamorelin (Most Popular - "The Clean Stack"):
Why this combination:
- Powerful synergy (8-15x GH)
- Minimal side effects (both very clean)
- Excellent for women
- Great body composition results
- Well-tolerated long-term
Dosing:
- Modified GRF: 100mcg + Ipamorelin: 100-200mcg
- 2-3x daily
- Post-workout + before bed minimum
Results:
- 5-8 lbs lean mass over 3-6 months
- Significant fat loss with proper diet
- Enhanced recovery and sleep
- Excellent overall transformation
Modified GRF + GHRP-2 (Stronger - "The Power Stack"):
Advantages:
- More powerful GH release than Ipamorelin
- Faster results possible
- Greater muscle gains potential
Trade-offs:
- Moderate hunger increase
- Slightly more side effects
- Still well-tolerated
Best for:
- Those who can tolerate hunger
- Maximum muscle building
- Willing to manage increased appetite
Modified GRF + GHRP-6 (Strongest - "The Bulking Stack"):
Most powerful combination:
- Highest GH release of all GHRPs
- Intense hunger (excellent for bulking)
- Maximum muscle-building potential
Side effects:
- Strong appetite increase (can be overwhelming)
- Nausea possible initially
- More intense overall
Best for:
- Serious bulking phases
- Hard gainers needing calories
- Those who can embrace intense hunger
Modified GRF + IGF-1 LR3 (Advanced):
Comprehensive growth:
- GH elevation (Modified GRF)
- Direct IGF-1 (IGF-1 LR3)
- Multiple anabolic pathways
- Powerful muscle-building stack
Advanced users only:
- More complex protocol
- Multiple peptides
- Requires experience
Modified GRF + Testosterone (Women - Advanced):
Maximum anabolic environment:
- For serious female bodybuilders only
- Significant virilization risk
- Medical supervision essential
- Dramatic physique changes possible
Modified GRF + Proper Training (ESSENTIAL):
Non-negotiable:
- Resistance training 4-5x weekly minimum
- Progressive overload critical
- Without training, minimal muscle gains
- Peptides amplify work, don't replace it
Modified GRF + High Protein (ESSENTIAL):
Nutritional requirements:
- Minimum 0.8-1g protein per lb bodyweight
- GH increases protein turnover
- Need building blocks for muscle
- Inadequate protein = wasted peptides
PRODUCT CERTIFICATES
FREQUENTLY ASKED QUESTIONS
What's the difference between CJC-1295 No DAC and with DAC?
NO DAC (Modified GRF 1-29): 30-minute half-life, 1-3x daily dosing, pulsatile GH spikes, EXCELLENT GHRP synergy (both pulsed together), mimics natural pattern, superior for stacking. WITH DAC: 6-8 day half-life, weekly dosing, sustained GH elevation, limited GHRP synergy, extreme convenience. For maximum results with GHRP stacking: choose NO DAC. For convenience without stacking: choose WITH DAC.
Do I need to stack Modified GRF with a GHRP or can I use it alone?
HIGHLY recommend stacking. Modified GRF alone: modest 2-3x GH increase. Modified GRF + GHRP together: 8-15x GH increase - massive synergy. This combination is the ENTIRE POINT of using No DAC version. Using alone wastes the potential. Always stack with Ipamorelin, GHRP-2, or GHRP-6 for optimal results. If unwilling to stack, consider CJC with DAC instead.
Which GHRP should I stack with Modified GRF?
IPAMORELIN (most popular): Clean, minimal side effects, excellent synergy, best for women. GHRP-2: More powerful GH release, moderate hunger increase, stronger results. GHRP-6: Strongest GH release, intense hunger (bulking), most powerful but most side effects. Recommendation: Start with Ipamorelin (cleanest), switch to GHRP-2/6 if wanting more power and can handle side effects.
How much muscle will I gain on Modified GRF + GHRP stack?
Realistic: 5-10 lbs lean mass over 3-6 months with intensive training and proper nutrition. Strength increases 20-30%. NOT rapid dramatic gains like steroids - gradual quality muscle that's keepable. Requires: 4-5x weekly resistance training, 0.8-1g protein per lb bodyweight, appropriate calories, consistent 3-6 month protocol. Results accumulate slowly but are substantial with commitment.
Can I just dose Modified GRF once per day before bed?
Yes - minimum effective protocol. Before bed dosing: enhances deep sleep, improves recovery, provides anti-aging benefits, convenient single daily injection. Results will be modest compared to 2-3x daily but still beneficial. For better body composition results: add post-workout dose (2x daily minimum). For maximum: morning + post-workout + bed (3x daily).
How do I time Modified GRF and GHRP together for synergy?
Inject BOTH at SAME TIME - within minutes of each other. Can mix in same syringe (common practice): Draw Modified GRF first, then draw GHRP, inject both together. Synergy requires simultaneous pituitary stimulation. Dosing separately hours apart = lost synergy = wasted potential. Always fasted (3+ hours after food). Wait 20-30 min post-injection before eating.
Will Modified GRF help with fat loss?
Yes, when combined with proper diet. GH enhances fat oxidation and metabolic rate, preferentially mobilizes visceral fat. However, MUST be in caloric deficit for net fat loss. Modified GRF + GHRP makes deficit more effective but doesn't create it. Realistic: enhanced fat loss with 200-500 calorie deficit + training. Works excellently for body recomposition (gain muscle while losing fat at maintenance calories).
How does Modified GRF + GHRP compare to real growth hormone?
Modified GRF + GHRP stimulates YOUR natural GH production through pituitary. Exogenous GH is direct injection. Properly stacked peptides can approach GH-level elevations (8-15x baseline). Peptides: Safer (self-regulating), no pituitary suppression, much cheaper, pulsatile (more natural). Exogenous GH: More potent, 24/7 elevation, higher risks, extremely expensive. Peptide stack is best natural optimization without GH's risks.
Can I use Modified GRF long-term or do I need to cycle?
Can use long-term with monitoring. Common approaches: 8-16 weeks on, 4-8 weeks off (assessment), OR continuous use indefinitely, OR 5 days on/2 days off (weekday protocol). No strict requirement to cycle - effects sustained with long-term use, no tolerance development reported. Cycling allows: baseline assessment, insulin sensitivity monitoring, cost management. Many use year-round successfully.
Will Modified GRF affect my insulin sensitivity?
Less concern than sustained elevation. Pulsatile GH (Modified GRF) returns to baseline between doses, potentially better for insulin sensitivity than chronic elevation. However, monitor glucose if using long-term high doses. Most users at standard doses (100-200mcg 2-3x daily) don't have issues. Consider metformin or berberine if concerned. Much cleaner metabolically than CJC with DAC's sustained elevation.
Can I mix Modified GRF and GHRP in the same syringe?
YES - common practice and recommended. Draw Modified GRF first (smaller volume typically), then draw GHRP into same syringe, inject both together. Simplifies protocol (one injection vs. two). Both peptides compatible. Ensures simultaneous timing for maximum synergy. Most experienced users do this.
How much does Modified GRF + GHRP stack cost monthly?
Depends on frequency and doses. Example (2x daily, 100mcg each): Modified GRF: ~1-2 vials monthly ($50-100), GHRP (Ipamorelin): ~1-2 vials monthly ($50-100), Total: $100-200 monthly. For 3x daily: ~$150-300 monthly. More economical than exogenous GH ($500-2000+ monthly) while providing comparable results when properly stacked. Best value in natural GH optimization.
Can I use Modified GRF while trying to conceive, pregnant, or breastfeeding?
NO. Not studied in pregnancy or breastfeeding. GH affects multiple systems - effects on fetal development unknown. Discontinue if trying to conceive, pregnant, or nursing. Wait until completely finished with reproductive period before using GH-elevating protocols.
⚠️ Important Legal & Safety Information
Regulatory Status:
This product is sold for research purposes. CJC-1295 No DAC (Modified GRF 1-29) is not approved by TGA (Australia) or FDA (USA) for human use. It is a research peptide developed for studying GH secretion and treating GH deficiency. By purchasing, you acknowledge this product is intended for research applications.
Research Context:
Modified GRF 1-29 extensively researched for GHRH replacement therapy and GH optimization. The GHRH + GHRP combination is gold standard in peptide research for maximizing natural GH secretion. Substantial data demonstrates synergistic GH elevation, favorable body composition changes, and good safety profile when properly dosed.
Medical Disclaimer:
Modified GRF 1-29 stimulates growth hormone production. Consultation with healthcare provider recommended if you have: Diabetes or insulin resistance, active cancer or cancer history (GH promotes cell growth), pituitary disorders, any significant medical conditions, are taking medications.
SHIPPING AND RETURNS
Shipping: Australia Post Express. Orders fulfilled within 24 hours of payment confirmation. Delivery: 2-5 business days Australia-wide. Tracking provided.
Returns: Due to the temperature-sensitive nature of research peptides, we cannot accept returns once shipped. We offer replacements for damaged, incorrect, or lost parcels. Please contact us within 48 hours of delivery for any issues.